Marie Sklodowska Curie actions (MicroILCs: Deciphering how the gut Microbiota influences Innate Lymphoid Cells in obesity. the MSCA-IF of Horizon 2020 Program. Grant agreement ID: 890545, 2021-2022. Principal Investigator: Dr. Marta Olivares; Coordinator: Prof. Yolanda Sanz.
MicroILCs investigates the role of innate lymphoid cells in the host response to obesogenic diets and their modulation by the gut microbiota.
Objectives
- Evaluate the role of intestinal bacteria with ILCs-stimulatory properties in the prevention of metabolic alterations in obesity
- Determine whether the effects of the selected bacteria on metabolism are ILCs-dependent
- Unravel the mechanisms underlying the communication between ILCs and the selected bacteria on diet-induced obesity
Strategy
We combine different study models and advanced analytical approaches, include the following:
- Murine models of diet-induced obesity
- Murine models with depleted lymphoid cells
- In vitro models of primary cell cultures
- Omics (metagenomics, metabolomics) and advanced immunological techniques
Impact
- A better mechanistic understanding of how gut microbiota communicates with the immune system
- Identification of new pathways and related mediators that constitute targets for obesity therapy