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Research of excellence

on microbiome and health

Introduction and Institutions

We investigate how the microbiome interacts with the environment (diet, stress) and the body to influence all aspects of health and disease. Specifically, we focus on the role that intestinal microorganisms and their metabolites play in the regulation of the immune, endocrine and nervous systems, impacting our physical and mental health. Our ultimate goal is to design microbiome-based diagnostic, preventive and therapeutic solutions to positively shape health promotion.

Ojectives

Mental health

Understand how psychological stress and the microbiome influences the development of mental and physical comorbidities, such as depression and cardiovascular disease.

Obesity and metabolic health

Understand how the gut microbiome and the diet regulate neuroendocrine and immune pathways involved in obesity and associated metabolic complications (e.g., type 2 diabetes).

Immune health

Understand how the gut microbiome trains and regulates the immune system, protecting against a range of diseases from infectious, like COVID-19, to autoimmune.

Healthy and sustainable nutrition

Exploit natural microbiomes (plants, soils, animals, marine, air) to improve the nutritional quality and safety of foods, protecting environmental and human health.

Bioinformatics and synthetic microbiotas

Develop user-friendly bioinformatic tools to better understand the functioning of complex biological systems and to produce bio-therapeutic bacteria and microbiotas for health promotion.

From the laboratory to society

Develop microbiome-based diagnostic, preventive and therapeutic strategies and generate impact, transferring the knowledge to the society and industry.

Publications

This is only a summary of our outstanding publications. To see all of them, click on THIS LINK.

Date	Title	Author/s	Medium
2021-07-15	Holdemanella biformis improves glucose tolerance and regulates GLP-1 signaling in obese mice	Marina Romaní-Pérez, Inmaculada López-Almela, Clara Bullich-Vilarrubias, Lola Rueda-Ruzafa, Eva M. Gómez Del Pulgar, Alfonso Benítez-Páez, Gerhard Liebisch, Jose Antonio Lamas, Yolanda Sanz	FASEB Journal
2021-11-14	Manipulation of the gut microbiome in gluten-intolerance	Marta Olivares, Alejandra Flor-Duro, Yolanda Sanz	Current Opinion Clinical Nutrition & Metabolic Care
2021-05-29	The Microbiota and the Gut-Brain Axis in Controlling Food Intake and Energy Homeostasis	Marina Romaní-Pérez, Clara Bullich-Vilarrubias, Inmaculada López-Almela, Rebeca Liébana-García, Marta Olivares, Yolanda Sanz	International Journal of Molecular Science
2023-01-08	Intestinal group 1 innate lymphoid cells drive macrophage-induced inflammation and endocrine defects in obesity and promote insulinemia	Rebeca Liébana-García, Marta Olivares, Carlos Francés-Cuesta, Teresa Rubio, Valerio Rossini, Guillermo Quintas, Yolanda Sanz	Gut Microbes
2023-08-01	Turning cooperative bacteria into probiotics for human health	Yolanda Sanz	Nature