Ingredients and foods to reduce the consumption of sugars in the population-SWEETFOOD. CDTI (Center for Industrial Technological Development). Ref: CIEN IDI-20170847; Principal Investigator: Prof. Yolanda Sanz.
SWEETFOOD evaluates the impact of sweeteners and other dietary compounds on the gut microbiota and metabolic health in collaboration with agri-food companies.
Objectives
- Evaluate the influence of various sweeteners and other dietary compounds on the composition of the human intestinal microbiota
- Investigate the effect of the microbiota on the biotransformation of compounds
- Study whether gut microbiota modifications caused by bioactive compounds can prevent obesity development and alterations in glucose metabolism in animal models
Strategy
We combine experiments in vitro gut bioreactors and well-established in vivo obesity models and apply advanced analytical techniques (LC-MS, multiplex arrays, metagenomics, etc.) to evaluate interactions between bioactive dietary components and the gut microbiota and their impact on obesity and glucose metabolism.
Impact
- Scientific evidence on the effects of new dietary compounds on obesity and metabolism, possibly mediated by gut microbiota
- Contribution to accelerate the possible commercialization of new ingredients with potential health benefits for the society and boosting a knowledge-based economy